THE ROLE OF END OF TREATMENT PET CT EVALUATED BY DEAUVILLE FIVE‐POINT SCALE AS PROGNOSTIC ROLE IN HODGKIN LYMPHOMA

Introduction: Positron Emission Tomography/Computed Tomography (PET CT) is crucial in staging and response assessment Hodgkin lymphoma (HL). While early tumor assessed through an interim PET (I-PET) by Deauville 5-point scale (DS), end of treatment (EoT) CT used to evaluate absence or presence metabolic disease, lacking scientific evidence a correlation between specific DS prognosis. Our study aimed analyse EoT demonstrate possible prognostic patient prognosis terms Relapse Free Survival (RFS) Overall (OS). Methods: We conducted monocentric retrospective patients with Classic HL, consecutively treated ABVD 2007 2018 at least 1 year follow-up favourable I-PET (DS1-3). images were collected submitted blind central revision assessment. Different values compared PFS. analysis was performed Kaplan-Meier curves Log-Rank test. Statistical significance considered for p <0.05. Results: 78 centrally reviewed. All are currently alive (OS=100%). After median 60 months (range 17-139) 17 (21%) had disease recurrence, RFS 60% 104 (median not reached). The time relapse 8 3-39). Splenic involvement, anemia (Hb<12 gr/dl) bulky diagnosis increased risk relapse. Patients DS1 (56 cases) showed 83% 100 Median worsened higher DS: 77 DS2 (12 cases), 2 DS3 (2 26 4 (3 14 DS5 (p <0.001) [Shown figure]. There longer frame DS1/2 DS≥3 34 respectively). Comparing DS, observed stable reduced activity, unlike indicates <0.001). Conclusion: suggests that systematic evaluation according allows more accurate identification unsatisfactory better stratification. joint the data shows recurrence case DS. In ending persistently significant FDG uptake some form consolidation could be investigated. Keywords: Diagnostic Prognostic Biomarkers, PET-CT, No conflicts interests pertinent abstract.